Former Major League Baseball pitcher Octavio Dotel was arrested earlier on Tuesday, while Luis Castillo, also a former player, was named by authorities as being part of the gang.
More than 40 raids were carried out across the country in connection with the case, according to Dominican Attorney General Jean Alain Rodriguez.
Rodriguez told reporters at a news conference that the case marks the largest anti-narcotics operation in the recent history of the Dominican Republic.
He said the gang allegedly run by nightclub owner Cesar Emilio Peralta controlled one of the region’s biggest drug trafficking operations, transporting illicit drugs including cocaine from South America to both the United States and Europe.
Reuters could not immediately locate Dotel, Castillo or Peralta, or their lawyers, for comment.